Hedonia is the Only 3-in-1 Medical Food formulated for the dietary management of nutritional deficiencies associated with depression.
Three nutrients in one capsule: EPA omega-3, L-Methylfolate and SAMe; each studied in depression in randomised controlled trials, and featured in international guidelines on natural products for depression.
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Rebalance Your Brain Chemistry
Hedonia is the Only 3-in-1 Medical Food formulated to correct nutritional deficiencies associated with depression.
Three nutrients in one capsule: EPA omega-3, L-Methylfolate and SAMe; each studied in depression in randomised controlled trials, and featured in international guidelines on natural products for depression.
- Free Shipping
- 60-day 100% money-back guarantee*
- Free Returns
Rebalance Your Brain Chemistry
Hedonia is the Only 3-in-1 Medical Food formulated for the dietary management of nutritional deficiencies associated with depression.
Three nutrients in one capsule: EPA omega-3, L-Methylfolate and SAMe; each studied in depression in randomised controlled trials, and featured in international guidelines on natural products for depression.
- Free Shipping
- 60-day 100% money-back guarantee*
- Free Returns
Rebalance Your Brain Chemistry
Now Available
Without a Prescription
- Three nutrients, One capsule, Four capsules a day. 1,440 mg of EPA omega-3, 20 mg of Quatrefolic® L-Methylfolate and 1,200 mg of SAMe daily, each at an amount that sits at or within the amount used in the published research on that nutrient in depression.
- Built to work alongside your treatment, NOT instead of it. Hedonia is designed for use with the care you are already receiving. That is what the medical food category exists for.
- Assessed by the people who write the guidelines. All three nutrients are covered in the 2022 international clinician guidelines from the World Federation of Societies of Biological Psychiatry and the Canadian Network for Mood and Anxiety Treatments.
- Protected by two US patents, and set out in the peer-reviewed literature. US 8,372,451 and US 9,662,359, both titled “Compositions and methods for treating depression”. The scientific rationale is published in Nutrients in 2024 by Tobin, Vuckovic and Sarris.
Now Available
Without a Prescription
- Three nutrients, One capsule, Four capsules a day. 1,440 mg of EPA omega-3, 20 mg of Quatrefolic® L-Methylfolate and 1,200 mg of SAMe daily, each at an amount that sits at or within the amount used in the published research on that nutrient in depression.
- Built to work alongside your treatment, NOT instead of it. Hedonia is designed for use with the care you are already receiving. That is what the medical food category exists for.
- Assessed by the people who write the guidelines. All three nutrients are covered in the 2022 international clinician guidelines from the World Federation of Societies of Biological Psychiatry and the Canadian Network for Mood and Anxiety Treatments.
- Protected by two US patents, and set out in the peer-reviewed literature. US 8,372,451 and US 9,662,359, both titled “Compositions and methods for treating depression”. The scientific rationale is published in Nutrients in 2024 by Tobin, Vuckovic and Sarris.
What is in each capsule, and how much
One capsule contains 450 mg of OmegaTex® omega-3 triglycerides, of which 360 mg is EPA, 81 mg is other omega-3 fatty acids and 9 mg is DHA; 5.0 mg of L-Methylfolate glucosamine as Quatrefolic® (which delivers 3.75 mg of the active form, L-5-Methyltetrahydrofolate); and 300 mg of Adonat® Premium SAMe stabilised powder.
The daily dose is four capsules, taken as two capsules twice a day with food. Across a full day that is 1,440 mg of EPA within 1,800 mg of total omega-3, 20 mg of Quatrefolic® (delivering 15 mg of L-Methylfolate) and 1,200 mg of SAMe.
Every amount stated elsewhere on this page is the daily amount unless it says otherwise.
Depression has a nutritional side, and it is not something you can fix at the dinner table
You are not alone. In 2021, an estimated 21 million American adults had at least one major depressive episode, according to the National Institute of Mental Health. It is not your fault. Depression is not just in your head.
Researchers have examined the nutritional differences that show up in people living with depression, and the picture that has emerged is that some of these differences are not easily changed by diet alone.
Hedonia addresses the nutritional side of depression care. It is the first and only medical food to bring three clinically studied nutrients together in one capsule, each at a daily amount used in the published research.
What is a medical food?
ABOUT THIS VIDEO
What is a medical food?
Medical food. What exactly is a medical food, and how is it different from a dietary supplement or a prescription drug?
This short video explains why Hedonia belongs to the medical food category, what that category means in the United States, and why Hedonia is intended for use under a doctor’s supervision.
[0:01] If you’re managing depression, you may have heard that nutrition can play a part.
[0:05] So you search online, and almost immediately things get confusing. One page is making huge promises about supplements. The next is talking about prescriptions and clinical treatment.
[0:15] Then you come across something called a medical food. That is the category Hedonia belongs to.
[0:21] Now, the name medical food can sound a little vague, but in the United States it has a very specific regulatory meaning. A medical food isn’t simply another dietary supplement, but it isn’t a drug either. What makes it different comes down to three things.
[0:36] First, it is formulated for the dietary management of a particular medical condition, not just for general health or well-being. Second, it is designed around a distinctive nutritional need linked to that condition. And third, it is intended to be used under a doctor’s supervision.
[0:54] For Hedonia, that condition is depression. More precisely, Hedonia is formulated for the dietary management of nutritional deficiencies associated with depression.
[1:05] That wording matters. This isn’t about an occasional low mood, everyday stress, or simply having a difficult week. Its intended use is deliberately specific.
[1:16] And that specific purpose shapes the formula. Hedonia provides three nutrients involved in the body’s own mood regulation pathways. The first is SAMe, short for S-adenosyl-L-methionine. SAMe plays a role in methylation and in the synthesis of neurotransmitters.
[1:34] The second is L-methylfolate. This is the active form of folate, ready for the body to use. And the third is EPA, an omega-3 fatty acid.
[1:45] All three nutrients have published evidence relating specifically to depression.
[1:50] Hedonia is available without a prescription, but that doesn’t mean it is intended to be used without medical guidance. It is designed to be taken under a doctor’s supervision.
[2:00] That isn’t simply a disclaimer tucked away in the small print. Doctor supervision is part of what defines the category.
[2:07] In practical terms, Hedonia is designed to be used with antidepressant treatment, not instead of it. And that one word, “with,” really matters.
[2:17] So, to be completely clear, Hedonia is not a treatment for depression. It is not a substitute for antidepressant medication, and it is not a substitute for therapy.
[2:26] Its role is more focused. It addresses the nutritional side of managing the condition.
[2:32] Put simply, Hedonia is a medical food made by Hedonia USA for the dietary management of nutritional deficiencies associated with depression and intended for use under a doctor’s supervision.
[2:44] In our next video, we’ll look at the published research behind each of the three nutrients.
Developed by a psychiatrist, after 35 years in practice
Hedonia was created by Dr. Alexander Vuckovic, MD, a psychiatrist with more than 35 years of clinical experience and an assistant professor of psychiatry, part-time, at an Ivy League medical school. He is a Diplomate of the American Board of Psychiatry and Neurology, a Distinguished Life Fellow of the American Psychiatric Association, and the named inventor on both US patents behind the formulation.
Dr. Vuckovic has spent his career on the relationship between nutrition and mental health, and on the gap it leaves in conventional depression care.
“In my 35 years of psychiatric practice, I have watched patients spend a great deal of money on supplements that were never designed for this. With Hedonia we set out to deliver the right ingredients, in the right amounts, in the right way.”
– Alexander Vuckovic MD, Founder of Hedonia
The Power of Hedonia as a Medical Food
Pioneering Depression Management Without a Prescription.
Hedonia stands apart in depression management because it is classified as a medical food. Medical foods are a distinct category, defined in the Orphan Drug Act of 1988 and regulated by the FDA, for products with a specific role in managing a particular condition.
Unlike over-the-counter supplements, a medical food is formulated to address distinctive nutritional requirements associated with a condition. And Hedonia is held to stricter standards than a typical supplement: it is manufactured to Current Good Manufacturing Practice, which is what assures consistent quality and potency batch after batch.
What a medical food is, and how it differs from a supplement or a drug
A medical food is a regulatory category in the United States, defined in the Orphan Drug Act of 1988 and in FDA regulation at 21 CFR 101.9(j)(8). It sits between dietary supplements and prescription drugs and is a third thing, not a version of either.
Three things define one. It is formulated for the dietary management of a specific condition rather than for general wellbeing. It addresses a distinctive nutritional requirement belonging to that condition, which is why the formulation is three ingredients rather than twenty.
Medical foods do not require FDA pre-approval, and they are not FDA-approved in the way a drug is. They must comply with FDA regulations for medical foods, including good manufacturing practice and labelling requirements. Familiar examples include Ensure and Pedialyte.
Hedonia is a medical food. It is not a dietary supplement and it is not a drug.
“I’m finally able to truly
enjoy life’s special moments again. Hedonia has helped me rediscover the joy I thought I’d lost forever.“
The Hedonia Difference
Premium Quality Ingredients
Hedonia uses pharmaceutical-grade ingredients, setting a standard as the only 3-in-1 patented medical food for people living with depression.
Superior EPA Omega-3
OmegaTex® · 1,440 mg of EPA a day, within 1,800 mg of total omega-3
- An ultra-high-EPA concentrate, against the 30 to 40% typical of ordinary fish oil supplements
- EPA makes up an ultra-high-EPA formulation, which is the ratio the research has favoured
- One of the highest-purity fish oils available
- Omega-3s are built into the membranes of brain cells, and the make-up of those membranes affects how the cells behave
Advanced Bioactive
L-Methylfolate
Quatrefolic® · 20 mg a day, delivering 15 mg of L-Methylfolate
- The most bioactive form of folate available, already in its active form and ready for the body to use
- No conversion required, which matters for the many people who convert folate slowly
- Particularly relevant for individuals with MTHFR gene variations
- Folate takes part in producing several of the neurotransmitters involved in mood
Bioavailable SAMe
Adonat® Premium · 1,200 mg a day
- Pharmaceutical-grade SAMe, one of the purest and most bioavailable forms available
- Manufactured by a proprietary process for maximum stability and potency
- Takes part in Methylation, a handover process involved in producing several of the neurotransmitters linked to mood
- Higher bioavailability means more of what you take reaches where it is needed
The research behind EPA omega-3
EPA and DHA are usually discussed together as though they were interchangeable. In depression research they have not been. The studies that have found an effect used formulations in which EPA made up most of the omega-3 content, and the most recent meta-analysis found reductions in depressive symptoms where EPA was 60% or more of the total, at doses between 1 and 2 grams a day. It found no significant effect at doses of 2 grams a day or more.
In Hedonia, EPA is an ultra-high-EPA formulation and the daily amount is 1,440 mg. Both figures sit inside the range associated with benefit.
Of Hedonia’s three nutrients this is the one where the guidelines are strongest. The 2022 WFSBP and CANMAT guidelines rate adjunctive omega-3 as recommended, which is their highest rating for any nutrient in depression.
The research behind L-Methylfolate
L-Methylfolate has been tested as an add-on to SSRI treatment. In the trial that used 15 mg a day, adding it improved response compared with the SSRI alone, with a number needed to treat of about six.
Hedonia provides more than 15 mg of L-Methylfolate a day, matching that trial. The form matters as much as the amount: the 2022 WFSBP and CANMAT clinician guidelines give adjunctive Methylfolate a positive recommendation in unipolar depression, and do not recommend plain folic acid.
The distinction between the active form and plain folic acid is recognised in clinical guidance. The 2022 guidelines from the World Federation of Societies of Biological Psychiatry and the Canadian Network for Mood and Anxiety Treatments give adjunctive Methylfolate a positive, though weak, recommendation in unipolar depression, and do not recommend plain folic acid.
On MTHFR: individuals carrying two copies of the common 677C>T variant tend to have higher homocysteine and lower serum folate than others. Around 15% to 25% of people are estimated to carry two copies.
What the research does not show: carrying an MTHFR variant is not a diagnosis and does not predict whether any individual will benefit. The American College of Medical Genetics and Genomics advises against routine MTHFR genotyping on the grounds of limited clinical utility. Hedonia does not require, recommend or interpret genetic testing.
The research behind SAMe
SAMe is short for S-adenosyl Methionine. The body already makes it, and it takes part in Methylation, which is best pictured as a handover: SAMe carries a small chemical package, called a Methyl group, and passes it to wherever it is needed next. That handover is one of the steps involved in producing several of the neurotransmitters linked to mood.
SAMe has been studied in depression since the 1970s, including in people already taking antidepressants. Hedonia provides 1,200 mg a day, within the 200 to 3,200 mg range used across the published trials.
A systematic review and meta-analysis in the American Journal of Psychiatry concluded that current evidence supports the adjunctive use of SAMe, Methylfolate and omega-3 with antidepressants to reduce depressive symptoms, and found primarily positive results in replicated studies for SAMe. The Cochrane review found SAMe superior to placebo when added to an SSRI. SAMe is in Hedonia as a synergistic partner to the omega-3 and the Methylfolate rather than as a standalone agent, on the divergent-pathways rationale set out in the 2024 Nutrients review.
Precision Delivery:
Hedonia Capsule Technology
Delayed timed release, for absorption throughout the day
Hedonia’s patented capsule design delivers the 3-in-1 formula where and when it is needed:
- The capsule stays intact and travels to the intestines for delayed release
- The capsule system spreads absorption through the day rather than all at once
The design is covered by US patents 8,372,451, granted 12 February 2013, and 9,662,359, granted 30 May 2017, both titled “Compositions and methods for treating depression”, with Dr. Alexander Vuckovic named as inventor.
“I’ve tried many different options. I never knew that my depression could be linked to specific nutritional deficiencies that I could not restore with diet.“
Our Promise to You
60
days
If you don’t feel a measurable improvement within 60 days, we’ll refund your order, no questions asked!
Pharmacies, grocery stores, vitamin outlets, and other retailers do not offer such a 100% money-back refund policy of this kind!
Special Introductory Offer!
$3/Day*
Less Than Your Latte
- Now Available Without a Prescription
- 60-Day 100% Money-Back Guarantee*
- Free Shipping & Free Returns
Hedonia offers more value
than purchasing individual OTC supplements.
Plus, you’re getting the assurance of a precisely formulated, scientifically backed medical food specifically designed for depression.
Take Advantage of This Limited Time Special Offer!
Hedonia offers more value
than buying the three nutrients separately
Hedonia offers more value than buying the three nutrients as separate supplements, with the assurance of a precisely formulated medical food designed for one purpose.
After the 60-day introductory period the price is $5.85 a day for a monthly delivery of 120 capsules. Shipping is free. Pause, change the delivery schedule or cancel at any time.
Why Hedonia Costs More – And Why It’s Worth It
We know the price looks high at first glance. Here is what is behind it.
Premium Ingredients
Hedonia uses branded, pharmaceutical-grade forms of all three nutrients: OmegaTex® ultra-high-EPA omega-3, Quatrefolic® L-Methylfolate and Adonat® Premium SAMe. These are not the generic, low-grade versions found in many supplements.
Effective Dosages
Many supplements contain trace amounts of their active ingredients. Hedonia delivers 1,440 mg of EPA, 15 mg of L-Methylfolate and 1,200 mg of SAMe a day, each at an amount used in published research in depression rather than an amount chosen to fit a price.
Patented Delivery
The time-release design, covered by US patents 8,372,451 and 9,662,359, spreads absorption through the day. SAMe in particular is sensitive to light and to contact with other compounds, and the dark green chlorophyllin design protects it.
Take Advantage of This Limited Time Special Offer!
What Hedonia does not claim
Hedonia is not a treatment for depression. It does not replace antidepressant medication and it does not replace therapy. It does one specific job, the nutritional side of managing the condition, under a doctor’s supervision.
Each of the three nutrients has been tested in randomised controlled trials in depression. The 3-in-1 combination itself has not yet been trialled as a whole, and a trial of the finished formulation is now being commissioned with Clinical Research Australia, to be registered publicly and published in the peer-reviewed literature in due course.
Before you start
Hedonia is available without a prescription, but it is intended for use under a doctor’s supervision. If you are being treated for depression, bring it to your next appointment and discuss it with the clinician looking after you.
Tell your doctor about every medicine you take before starting Hedonia, in particular any antidepressant. If you are pregnant, nursing, diagnosed with bipolar disorder, and/or taking MAO Inhibitors, you should consult with your doctor first. Speak to your doctor first if you take anticoagulant medication or levodopa. If you are having surgery, stop taking Hedonia two weeks beforehand. Some people notice mild stomach upset or headache, and SAMe can occasionally affect sleep.
Do not stop or change a prescribed medication because you have started taking Hedonia.
Frequently Asked Questions
Here are answers to the most often asked questions:
Do I need a prescription for Hedonia?
No. Hedonia does not require a prescription as long as you are under the care of a physician for depression.
Can Hedonia be combined with any antidepressants?
Yes. As a medical food, Hedonia complements all antidepressants. We always recommend you speak with your doctor before adding Hedonia to your daily routine.
As a Medical Food, how is Hedonia different from ordinary supplements?
Hedonia is not a supplement or a drug. It is a patented breakthrough medical food for the management of depression. Medical Foods are a distinct category defined by the Orphan Drug Act of 1988. Unlike general supplements, medical foods are formulated to meet the distinctive nutritional requirements associated with particular diseases or conditions. They are an important and often complementary category of therapeutic agents known to address disease through a nutritional pathway.
Hedonia embodies this definition by addressing the specific nutritional deficiencies often seen in individuals with depression. This targeted, science-based approach sets Hedonia apart from general supplements. It offers a level of specificity and quality not typically found in over-the-counter products, providing a more focused and potentially more effective nutritional intervention for individuals struggling with depression. As a medical food, Hedonia is subject to stricter FDA guidelines than typical supplements. It’s manufactured to pharmaceutical-grade standards, ensuring consistent quality and potency. Well-known medical foods brands include Pedialyte and Ensure. For more information watch this video.
How long does it take to feel the effects of Hedonia?
Everyone’s brain chemistry is different. While you may feel the effects of Hedonia in a few weeks to a couple of months after starting treatment, many people notice some beneficial effects much sooner.
For optimal results and to experience the full benefits of Hedonia, take two capsules in the morning and two in the evening. This consistent dosage ensures continuous support for your brain’s neurotransmitter levels, promoting sustained well-being and mental clarity.
Are there known weight gain, insomnia, or lower libido side effects associated with Hedonia?
Hedonia is not associated with weight gain, insomnia, or sexual dysfunction. If you are pregnant, nursing, diagnosed with bipolar disorder, and/or taking MAO Inhibitors, you should consult with your doctor first.
How does Hedonia simplify depression management compared to the supplement approach?
Hedonia revolutionizes depression management by combining three key ingredients in a single, powerful & convenient capsule. Hedonia eliminates the need to purchase and remember to take different nutritional supplements. This streamlined solution provides the optimal dosage of essential components in one easy-to-take formulation specifically designed to support those managing depression. With Hedonia, you simplify your regimen while ensuring you get the right balance of key ingredients – all without the inconvenience of juggling multiple supplements.
Why is Hedonia premium priced?
Hedonia is the first and only medical food to deliver the right dosage of 3 key clinically studied nutrients to help correct the nutritional imbalances and deficiencies associated with people suffering from depression. Unfortunately, these nutrients, while available individually, are often not of uniform quality or convenient to use and cannot be easily consumed at the levels sufficient to correct a depressed person’s deficiencies.
Hedonia only sources the highest premium quality ingredients for optimum potency, absorption, and bioavailability. One of the key nutrients in Hedonia is SAMe. It is known to be very susceptible to light and when in contact with other key compounds can lose its potency. That’s why Hedonia is delivered in a dual chamber capsule design to ensure the right potency and bioavailability of the active ingredients. For these reasons, Hedonia costs more to manufacture. Hedonia is backed by a 60-day money-back policy. If you’re not completely satisfied, we’ll refund your purchase price. No Questions Asked.
Is Hedonia FDA-approved?
Medical Foods are a distinct category defined by the Orphan Drug Act of 1988. While it doesn’t require FDA pre-approval, it must comply with FDA regulations for medical foods, including good manufacturing practices and appropriate labeling.
What are the 3 main ingredients in Hedonia?
Three nutrients. The daily dose is four capsules, taken as two capsules twice a day, and it provides 1,440 mg of EPA omega-3 as OmegaTex®, from 1,800 mg of total omega-3; 20 mg of L-Methylfolate glucosamine as Quatrefolic® (equivalent to 15 mg of L-Methylfolate); and 1,200 mg of SAMe as Adonat® Premium.
That is the entire formulation. There is no proprietary blend and no undisclosed amounts.
What are all of Hedonia's ingredients?
Each capsule provides 360 mg of EPA from 450 mg of total omega-3, 5 mg of Quatrefolic® (equivalent to 3.75 mg of L-methylfolate), and 300 mg of SAMe.
Product labels normally state amounts per capsule, and research on these nutrients normally states amounts per day. Both are shown here so the two are not confused.
How do I take Hedonia?
The recommended dosage is two capsules twice daily, preferably with meals. Always follow the instructions on the label or as directed by your healthcare provider.
What are the details of the 60-day money-back guarantee?
Hedonia is backed by a 60-day 100% money-back guarantee. We want you to try Hedonia risk free. If you do not feel a difference, you can return it for a full refund. No questions asked.
* What Are the Terms of the Special Introductory Offer?
We want you to try Hedonia for 60 Days for you to feel the difference it makes in your life. That’s why we’ve cut the cost in half for your first 60 days and offer a hassle-free money-back refund policy. If you don’t feel better we’ll refund every penny. No questions asked. After, this 60-day risk-free trial period, the price is $5.85/Day for your monthly delivery of 120 capsules. Shipping is free and your order is backed by our 100% satisfaction guarantee*. This means you can pause, change your delivery cadence or cancel your monthly delivery anytime.
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Hedonia is classified as a medical food product. It is specially formulated to address the unique nutritional needs associated with depression. It is recommended that you check with your doctor before taking or adding Hedonia to your daily routine. If you are pregnant, nursing, diagnosed with bipolar disorder, and/or taking MAO Inhibitors, you should consult with your doctor first.